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Description

PE134000: α-GalNAc-PEG3-AzideC14H26N4O8 378. 38 An D N acetylgalactosamine (GalNAc) ligand equipped with an azide handle through a hydrophilic PEG3 spacer. The terminal azide couples to alkynes via copper catalyzed azide alkyne cycloaddition (CuAAC) or to DBCO and related strained alkynes via copper free click chemistry, forming stable 1,2,3 triazole linkages. This compound enables the construction of hepatocyte targeted therapeutics and research tools that exploit the

22 / An α-D-galactose ligand equipped with an amine-functionalized linker through a short ethyl spacer

peracetylated)

T Antigen (Threonine)

/ Fmoc-Thr((Ac)7-Mal-β-D)-OH / Fmoc-Thr(β-D-Mal)-OH

/ α-GalNAc-PEG5000-Thiol / α-D-GalNAc-PEG5000-Thiol

Fmoc-Ser(β-D-Lactose)-OH

2-[2-(2-mercaptoethoxy)ethoxy]ethyl β-D-galactopyranoside

7]oxepino[4

Fmoc-Ser(β-L-Rhamnose)-OH (Peracetate)

/ CD24(41-51)-TF(41

The azide can be covalently coupled to alkyne partners via copper-catalyzed azide-alkyne cycloaddition (CuAAC)

Actelion-d4